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Literature summary for 3.4.22.61 extracted from

  • Afshar, G.; Jelluma, N.; Yang, X.; Basila, D.; Arvold, N.D.; Karlsson, A.; Yount, G.L.; Dansen, T.B.; Koller, E.; Haas-Kogan, D.A.
    Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cells (2006), Cancer Res., 66, 4223-4232.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
radiation increases caspase-8 expression and activity Homo sapiens

Application

Application Comment Organism
medicine caspase-8 activation mediates p53-independent apoptosis of glioma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IETD-fmk
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte no change in activity after irradiation Homo sapiens
-
glioma cell
-
 Homo sapiens
-
SF-188 cell increase in caspase-8 transcript levels and activity after irradiation Homo sapiens
-
U-251 MG cell increase in caspase-8 transcript levels and activity after irradiation Homo sapiens
-
U-87MG cell no change in activity after irradiation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IETD-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens IETD + 7-amino-4-trifluoromethylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
caspase-8
-
 Homo sapiens