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Literature summary for 3.4.22.61 extracted from

  • Kahns, S.; Kalai, M.; Jakobsen, L.D.; Clark, B.F.; Vandenabeele, P.; Jensen, P.H.
    Caspase-1 and caspase-8 cleave and inactivate cellular parkin (2003), J. Biol. Chem., 278, 23376-23380.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
transient coexpression of caspase wild-type parkin in HEK-293 cells identifies caspase-1, caspase-3 and caspase-8 as efficient inducers of parkin cleavage Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
parkin + H2O Homo sapiens cleavage at Asp126-Ser127. Caspase-1 and caspase-8 dependent parkin cleavage in sporadic Parkinson‘s disease may play an important role in the degenerative process by initiating a vicious circle that leads to the accumulation of toxic parkin substrates, e.g. alpha-synuclein ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
parkin + H2O cleavage at Asp126-Ser127 Homo sapiens ?
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 ?
parkin + H2O cleavage at Asp126-Ser127. Caspase-1 and caspase-8 dependent parkin cleavage in sporadic Parkinson‘s disease may play an important role in the degenerative process by initiating a vicious circle that leads to the accumulation of toxic parkin substrates, e.g. alpha-synuclein Homo sapiens ?
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 ?