Literature summary for 3.4.22.61 extracted from

Blanchard, H.; Donepudi, M.; Tschopp, M.; Kodandapani, L.; Wu, J.C.; Grutter, M.G.
Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-CHO complex (2000), J. Mol. Biol., 302, 9-16.

Search for more literature for 3.4.22.61

Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-DEVD-aldehyde	the inhibitor interacts favourably with the enzyme in subsite S4	Homo sapiens
tert-butyloxycarbonyl-IETD-aldehyde	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14790	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target	Homo sapiens	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000001	-	tert-butyloxycarbonyl-IETD-aldehyde	-	Homo sapiens
0.000002	-	benzyloxycarbonyl-DEVD-aldehyde	-	Homo sapiens

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Release 2023.1 (January 2023)