Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cowpox serpin CrmA | CrmA, a pox virus-encoded serpin attenuates the ability of FLICE to activate downstrean caspases | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CD95 and TNFR-1 death receptors initiate apoptosis by recruiting FLICE/MACH, which represents the apical triggering member of the protease death cascade and a target for the cell death inhibitor CrmA | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14790 | recombinant enzyme expressed in Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FLICE2 + H2O | - |
Homo sapiens | ? | - |
? | |
LAP3 + H2O | - |
Homo sapiens | ? | - |
? | |
LAP6 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | Mch2 and ICH1 are effectively cleaved only in the presence of native extract | Homo sapiens | ? | - |
? | |
additional information | CD95 and TNFR-1 death receptors initiate apoptosis by recruiting FLICE/MACH, which represents the apical triggering member of the protease death cascade and a target for the cell death inhibitor CrmA | Homo sapiens | ? | - |
? | |
Tx + H2O | - |
Homo sapiens | ? | - |
? | |
Yama + H2O | - |
Homo sapiens | ? | - |
? |