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Literature summary for 3.4.22.61 extracted from

  • Chang, H.Y.; Yang, X.
    Proteases from cell suicide: functions and regulation of caspases (2000), Microbiol. Mol. Biol. Rev., 64, 821-846.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme acts as apoptosis initiator. Animals deficient in caspase-8 are embryonically lethal at approximately E12.5. Abnormal heart development and vascular hyperemia, EF resistant to Fas, TNF-alpha, and DR3 but exhibit normal sensitivity to UV, etoposide, low serum and staurosporine, death receptor signaling to JNK and NF-kappaB intact ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 possesses weak protease activity which may allow it to cleave other procaspase-8 molecules when in close proximity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the preferred cleavage sequence is LETD-/- Homo sapiens ?
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?
additional information the enzyme acts as apoptosis initiator. Animals deficient in caspase-8 are embryonically lethal at approximately E12.5. Abnormal heart development and vascular hyperemia, EF resistant to Fas, TNF-alpha, and DR3 but exhibit normal sensitivity to UV, etoposide, low serum and staurosporine, death receptor signaling to JNK and NF-kappaB intact Homo sapiens ?
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?