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Literature summary for 3.4.22.60 extracted from

  • Cassel, J.A.; McDonnell, M.E.; Velvadapu, V.; Andrianov, V.; Reitz, A.B.
    Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function (2012), Biochimie, 94, 1974-1981.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.60

Activating Compound

Activating Compound Comment Organism Structure
2-(4-methoxyphenyl)-4-(piperazin-1-yl)quinoline 9% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
2-(4-methoxyphenyl)-N-[2-(morpholin-4-yl)ethyl]quinolin-4-amine 4% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine 17% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine 26% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine 123% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine 117% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
N,N-diethyl-N'-[2-(4-ethylphenyl)quinolin-4-yl]propane-1,3-diamine 24% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens
N,N-diethyl-N'-[2-(4-methoxyphenyl)quinolin-4-yl]propane-1,3-diamine 124% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
PARP + H2O Homo sapiens
-
 ?
-
 ?
TAR DNA binding protein 43 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H4 cell
-
 Homo sapiens
-
neuroglioma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-DEVD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-acetyl-DEVD + 7-amino-4-methylcoumarin
-
 ?
PARP + H2O
-
 Homo sapiens ?
-
 ?
TAR DNA binding protein 43 + H2O
-
 Homo sapiens ?
-
 ?