Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of caspase-7 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | active caspase-7 colocalizes with internalized TNF-R1 receptosomes, molecular components of a potential signalling cascade from TNF-R1 to A-SMase via caspase-7 actually localize in the same subcellular compartment. Direct association of caspase-7 and A-SMase within TNF receptosomes | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
20000 | - |
1 * 31000 + 1 * 20000, active caspase-7, SDS-PAGE | Homo sapiens |
31000 | - |
1 * 31000 + 1 * 20000, active caspase-7, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acid sphingomyelinase + H2O | Homo sapiens | caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | cleavage of procaspase-7 of 35 kDa to the active forms of 31 and 20 kDa, TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acid sphingomyelinase + H2O | caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes | Homo sapiens | ? | - |
? | |
acid sphingomyelinase + H2O | A-SMase, caspase-7 activates acid sphingomyelinase induced by TNF, overview | Homo sapiens | ? | - |
? | |
acid sphingomyelinase + H2O | acid sphingomyelinase, i.e. A-SMase, free or as fusion protein A-SMase-EGFP, a glycosylated protein, caspase-7 activates A-SMase induced by TNF, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 31000 + 1 * 20000, active caspase-7, SDS-PAGE | Homo sapiens |
monomer | 1 * 35000-37000, procaspase-7, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
caspase-7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of caspase-7 inhibits TNF-induced cleavage and activation of A-SMase | Homo sapiens |
additional information | active caspase-7 colocalizes with internalized TNF-R1 receptosomes. TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes | Homo sapiens |