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Literature summary for 3.4.22.60 extracted from

  • Soares, J.; Lowe, M.M.; Jarstfer, M.B.
    The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate (2011), Biochemistry, 50, 9046-9055.
    View publication on PubMed
Search for more literature for 3.4.22.60

Protein Variants

Protein Variants Comment Organism
D628A site-directed mutagenesis, caspase-7 resistant mutant, retains telomerase activity Homo sapiens
E286A site-directed mutagenesis, inactive mutant Homo sapiens
E286A/D628A site-directed mutagenesis, inactive mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ac-DEVD-fluoromethylketone a caspase-7 inhibitor Homo sapiens
Z-VAD-fluoromethylketone a Pan caspase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human telomerase + H2O caspase-7 cleaves human telomerase, hTERT, at residues E286 and D628, generation of three major proteolytic fragments, cleavage site determination using caspase-7 resistant substrate mutants D129A, D637A, and D129A/D637A, overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens