Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | procaspase-7 is physiologically cleaved and activated by caspase-2, optimal conditions, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of procaspase-7 in Escherichia coli strain BL21(DE3) | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C186S | site-directed mutagenesis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-7 is an important executioner caspase capable of conducting most of apoptotic program in cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-7 is cleaved at Asp198 and Asp206 and activated by caspase-2 | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant procaspase-2 from Escherichia coli strain BL21(DE3) by nickel affinity and ion exchange chromatography to over 95% | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
SK-N-BE(2) cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-7 is an important executioner caspase capable of conducting most of apoptotic program in cells | Homo sapiens | ? | - |
? | |
VDVAD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | VDVAD + 7-amino-4-methylcoumarin | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |