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Literature summary for 3.4.22.60 extracted from

  • Stegh, A.H.; Kesari, S.; Mahoney, J.E.; Jenq, H.T.; Forloney, K.L.; Protopopov, A.; Louis, D.N.; Chin, L.; DePinho, R.A.
    Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma (2008), Proc. Natl. Acad. Sci. USA, 105, 10703-10708.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Bcl2L12 is a direct caspase-7-binding and inhibitory protein affecting effector caspase activation, knockdown of Bcl2L12 or to a lesser extent of XIAP and Bcl-2 results in enhanced caspase-7 activation, regulation, overview Homo sapiens
additional information alphaB-crystallin specifically interacts with and inhibits caspase-3, but not caspase-7 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-7 is involved in apoptosis and glioblastoma, regulation, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary Homo sapiens
-
brain cancer cell
-
Homo sapiens
-
glioblastoma cell
-
Homo sapiens
-
glioma cell
-
Homo sapiens
-
LN-235 cell
-
Homo sapiens
-
LN-443 cell a glioma cell line Homo sapiens
-
U-373MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-7 is involved in apoptosis and glioblastoma, regulation, overview Homo sapiens ?
-
?