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Literature summary for 3.4.22.60 extracted from

  • Jung, E.J.; Kim, D.R.
    Apoptotic cell death in TrkA-overexpressing cells: kinetic regulation of ERK phosphorylation and caspase-7 activation (2008), Mol. Cells, 26, 12-17.
    View publication on PubMed
Search for more literature for 3.4.22.60

Activating Compound

Activating Compound Comment Organism Structure
additional information tyrosine kinase TrkA activates caspase-7 in apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens tyrosine kinase TrkA overexpression induces substantial cell death even in the absence of NGF, by stimulating ERK phosphorylation and caspase-7 activation leading to PARP cleavage, mechanism, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-7 is activated by processing to the mature caspase-7 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
SK-N-MC cell
-
 Homo sapiens
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U2-OS cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information tyrosine kinase TrkA overexpression induces substantial cell death even in the absence of NGF, by stimulating ERK phosphorylation and caspase-7 activation leading to PARP cleavage, mechanism, overview Homo sapiens ?
-
 ?