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Literature summary for 3.4.22.60 extracted from

  • Houde, C.; Banks, K.G.; Coulombe, N.; Rasper, D.; Grimm, E.; Roy, S.; Simpson, E.M.; Nicholson, D.W.
    Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice (2004), J. Neurosci., 24, 9977-9984.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmenation in Casp3-/-mice Homo sapiens
medicine strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmenation in Casp3-/-mice, caspase-7 is a caspase-3 surrogate in Casp3-/-mice Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens
cloned into the NcoI site of the pET11d vector and expression in Escherichia coli BL21codon+ Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
B6 and 129 strain, adults and embryos
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
spleen
-
Mus musculus
-
stomach
-
Mus musculus
-
telencephalon precursor neurons Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-DEVD-7-amido-4-methylcoumarin + H2O
-
Mus musculus Ac-DEVD + 7-amino-4-methylcoumarin
-
?
inhibitor of caspase-actived DNase + H2O human caspase-7 is less efficient than caspase-3 at cleaving Homo sapiens ?
-
?
inhibitor of caspase-actived DNase + H2O mouse caspase-7 and caspase-3 are equally efficient at cleaving Mus musculus ?
-
?