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Literature summary for 3.4.22.59 extracted from

  • Lee, P.Y.; Cho, J.H.; Chi, S.W.; Bae, K.H.; Cho, S.; Park, B.C.; Kim, J.H.; Park, S.G.
    Expression of the pro-domain-deleted active form of caspase-6 in Escherichia coli (2014), J. Microbiol. Biotechnol., 24, 719-723.
    View publication on PubMed
Search for more literature for 3.4.22.59

Cloned(Commentary)

Cloned (Comment) Organism
a caspase-6 with a 23-amino-acid deletion in the pro-domain is expressed in Escherichia coli BL21 Codon Plus (DE3) RIL cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C163S inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z -VEID-fluoromethylketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lamin A + H2O Homo sapiens
-
 ?
-
 ?
tubulin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55212
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lamin A + H2O
-
 Homo sapiens ?
-
 ?
N-acetyl-VEID-4-nitroanilide + H2O
-
 Homo sapiens N-acetyl-VEID + 4-nitroaniline
-
 ?
tubulin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * about 30000, caspase-6 with a 23-amino-acid deletion in the pro-domain, SDS-PAGE Homo sapiens