Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.59 extracted from

  • LeBlanc, A.C.
    Caspase-6 as a novel early target in the treatment of Alzheimers disease (2013), Eur. J. Neurosci., 37, 2005-2018.
    View publication on PubMed
Search for more literature for 3.4.22.59

Protein Variants

Protein Variants Comment Organism
C163A the catalytic mutant is unabble to self-activate Mus musculus
C163A the catalytic mutant is unable to self-activate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-VAD-fluoromethylketone
-
 Homo sapiens
Z-VAD-fluoromethylketone
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
actinin-4 + H2O Mus musculus
-
 ?
-
 ?
actinin-4 + H2O Homo sapiens
-
 ?
-
 ?
alpha-tubulin + H2O Mus musculus cleaved at Asp438 ?
-
 ?
alpha-tubulin + H2O Homo sapiens cleaved at Asp438 ?
-
 ?
amyloid precursor protein + H2O Mus musculus
-
 ?
-
 ?
amyloid precursor protein + H2O Homo sapiens
-
 ?
-
 ?
drebrin + H2O Mus musculus
-
 ?
-
 ?
drebrin + H2O Homo sapiens
-
 ?
-
 ?
p97 + H2O Mus musculus the main cleavage site is at VAPD179 ?
-
 ?
p97 + H2O Homo sapiens the main cleavage site is at VAPD179 ?
-
 ?
pro-caspase-6 + H2O Mus musculus the enzyme can self-process and self-activate caspase-6 + ?
-
 ?
pro-caspase-6 + H2O Homo sapiens the enzyme can self-process and self-activate caspase-6 + ?
-
 ?
spinophilin + H2O Mus musculus
-
 ?
-
 ?
spinophilin + H2O Homo sapiens
-
 ?
-
 ?
tau protein + H2O Mus musculus cleaved at Asp402 ?
-
 ?
tau protein + H2O Homo sapiens cleaved at Asp402 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55212
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
dendritic cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
actinin-4 + H2O
-
 Mus musculus ?
-
 ?
actinin-4 + H2O
-
 Homo sapiens ?
-
 ?
alpha-tubulin + H2O cleaved at Asp438 Mus musculus ?
-
 ?
alpha-tubulin + H2O cleaved at Asp438 Homo sapiens ?
-
 ?
amyloid precursor protein + H2O
-
 Mus musculus ?
-
 ?
amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?
drebrin + H2O
-
 Mus musculus ?
-
 ?
drebrin + H2O
-
 Homo sapiens ?
-
 ?
p97 + H2O the main cleavage site is at VAPD179 Mus musculus ?
-
 ?
p97 + H2O the main cleavage site is at VAPD179 Homo sapiens ?
-
 ?
pro-caspase-6 + H2O the enzyme can self-process and self-activate Mus musculus caspase-6 + ?
-
 ?
pro-caspase-6 + H2O the enzyme can self-process and self-activate Homo sapiens caspase-6 + ?
-
 ?
spinophilin + H2O
-
 Mus musculus ?
-
 ?
spinophilin + H2O
-
 Homo sapiens ?
-
 ?
tau protein + H2O cleaved at Asp402 Mus musculus ?
-
 ?
tau protein + H2O cleaved at Asp402 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Casp6
-
 Mus musculus
Casp6
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus caspase-6 mRNA levels decrease 3fold in the brains of adult mice exposed to an enriched environment down
Mus musculus caspase-6 mRNA levels increase 2-3fold in the aging mouse cortex and hypothalamus up

General Information

General Information Comment Organism
physiological function caspase-6 activity is intimately associated with the pathologies of Alzheimer's disease. The enzyme is already highly abundant at the beginning of the symptomatic phase of the disease. Caspase-6 activation is necessary for increased amyloid beta levels in serum-deprived primary human neurons. Caspase cleavage of tau protein impairs microtubule polymerization and stability, and may lead to tangle formation. The enzyme also plays a role in axonal degeneration of both peripheral and central nervous system Homo sapiens