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Literature summary for 3.4.22.59 extracted from

  • van Raam, B.J.; Ehrnhoefer, D.E.; Hayden, M.R.; Salvesen, G.S.
    Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6 (2013), Cell Death Differ., 20, 86-96.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.59

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
carbobenzoxy-Val-Ala-Asp-fluoromethylketone
-
 Homo sapiens
Q-VD-OPH
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
caspase-8 + H2O Homo sapiens caspase-6 cleaves, but does not activate caspase-8 ?
-
 ?
additional information Homo sapiens the enzyme does not cleave receptor-interacting protein kinase-3 ?
-
 ?
PARP + H2O Homo sapiens
-
 ?
-
 ?
receptor-interacting protein kinase-1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
caspase-8 + H2O caspase-6 cleaves, but does not activate caspase-8 Homo sapiens ?
-
 ?
additional information the enzyme does not cleave receptor-interacting protein kinase-3 Homo sapiens ?
-
 ?
N-acetyl-VEID-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-acetyl-VEID + 7-amino-4-methylcoumarin
-
 ?
PARP + H2O
-
 Homo sapiens ?
-
 ?
receptor-interacting protein kinase-1 + H2O
-
 Homo sapiens ?
-
 ?
receptor-interacting protein kinase-1 + H2O cleavage site between 324-Asp and 325-Cys Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Casp.6
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function caspase-6 has a supporting role in apoptosis by cleaving receptor-interacting-kinase-1, thus preventing production of inflammatory cytokines as well as inhibiting the necroptotic pathway Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.39
-
 receptor-interacting protein kinase-1 in 0.8 M sodium citrate, 20 mM PIPES, 100 mM NaCl, pH 7.2, 5 mM dithiothreitol, at 37°C Homo sapiens