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Literature summary for 3.4.22.59 extracted from

  • Watanabe, C.; Shu, G.L.; Zheng, T.S.; Flavell, R.A.; Clark, E.A.
    Caspase 6 regulates B cell activation and differentiation into plasma cells (2008), J. Immunol., 181, 6810-6819.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information proliferation and cell death are not enhanced in Casp6 KO B cells, immunoresponses, overview. B cells from Casp6 knockout mice examined ex vivo have more cells in G1 than wild-type B cells, and mitogen-induced G1 entry of Casp6 KO B cells is much faster than that of wild-type B cells. Even so, S phase entry and proliferation are not increased in Casp6 KO B cells. Rather than proliferating, activated Casp6 KO B cells preferentially differentiate into syndecan-1+ plasma cells and produce Abs. In Casp6 KO mice compared with wild-type mice, serum levels of IgG1, IgG2a, and IgG2b are increased and Ag-specific Ab responses are also enhanced along with increased percentages of syndecan-1+ plasma cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase 6 is an effector caspase in apoptosis pathways and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry, Casp6 is cleaved after B cell activation ?
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 ?
additional information Mus musculus C57BL/6 caspase 6 is an effector caspase in apoptosis pathways and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry, Casp6 is cleaved after B cell activation ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6 mice
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Mus musculus C57BL/6
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 C57BL/6 mice
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification Casp6 is cleaved after B cell activation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase 6 is an effector caspase in apoptosis pathways and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry, Casp6 is cleaved after B cell activation Mus musculus ?
-
 ?
additional information caspase 6 is an effector caspase in apoptosis pathways and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry, Casp6 is cleaved after B cell activation Mus musculus C57BL/6 ?
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 ?

Synonyms

Synonyms Comment Organism
Casp6
-
 Mus musculus