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Literature summary for 3.4.22.59 extracted from

  • Eguchi, R.; Tone, S.; Suzuki, A.; Fujimori, Y.; Nakano, T.; Kaji, K.; Ohta, T.
    Possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells (2009), Exp. Cell Res., 315, 327-335.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-VAD-fluoromethyl ketone i.e. zVAD-fmk, a broad-spectrum caspase inhibitor, which inhibits activation of caspase-6 and caspase-3, but not of caspase-7 Homo sapiens
additional information carbobenzyloxy-LEHD-fluoromethyl ketone specifically inhibits initiator caspase-9 upstream of caspase-3 and caspase-3 activation, but fails to inhibit caspase-6 and caspase-7 activation Homo sapiens
SB203580 a p38 inhibitor, also inhibits activation of caspase-6, caspase-3, and caspase-7 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells, caspase-6 is responsible for DNA ladder formation durirng hypoxia, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell HUVECs are isolated from human umbilical cord Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information possible involvement of caspase-6 and -7 but not caspase-3 in the regulation of hypoxia-induced apoptosis in tube-forming endothelial cells, caspase-6 is responsible for DNA ladder formation durirng hypoxia, overview Homo sapiens ?
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