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Literature summary for 3.4.22.59 extracted from

  • Suzuki, A.; Kusakai, G.; Kishimoto, A.; Shimojo, Y.; Miyamoto, S.; Ogura, T.; Ochiai, A.; Esumi, H.
    Regulation of caspase-6 and FLIP by the AMPK family member ARK5 (2004), Oncogene, 23, 7067-7075.
    View publication on PubMed
Search for more literature for 3.4.22.59

Application

Application Comment Organism
medicine caspase-6 is phosphorylated by AMP-activated protein kinase related kinase 5 at Ser257 in colorectal cancer cells, leading to inactivation of caspase-6 and resulting in resistance to cell death via cFLIPs protection and leading to resistance to the FAS ligand/Fas system Homo sapiens

Protein Variants

Protein Variants Comment Organism
S257A mutant caspase-6, not phosphorylated in the presence of active AMPK-related kinase 5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Ala-Asp-fluoromethylketone
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cFLIP + H2O
-
 Homo sapiens ?
-
 ?