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Literature summary for 3.4.22.59 extracted from

  • Horowitz, P.M.; Patterson, K.R.; Guillozet-Bongaarts, A.L.; Reynolds, M.R.; Carroll, C.A.; Weintraub, S.T.; Bennett, D.A.; Cryns, V.L.; Berry, R.W.; Binder, L.I.
    Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease (2004), J. Neurosci., 24, 7895-7902.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine role for caspase-6 and N-terminal truncation of tau during neurovibrillary tangle evolution and the progression of Alzheimer´s disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Tau + H2O microtubule-associated protein, caspase-6 cleaves the N-terminus at D13 of tau in vitro Homo sapiens ?
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