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Literature summary for 3.4.22.59 extracted from

  • Kalinin, A.E.; Kalinin, A.E.; Aho, M.; Uitto, J.; Aho, S.
    Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region (2005), J. Invest. Dermatol., 124, 46-55.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloned into pET-23 bacterial expression vector Homo sapiens
expression in MDCK cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Ala-Asp-fluoromethylketone
-
Homo sapiens
ZVEID-fmk caspase 6-specific inhibitor, reduces apoptosis and prevents periplakin cleavage in adherent cells, although it does not completely prevent cells from detaching Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
periplakin + H2O caspase 6 cleaves periplakin at an unconventional recognition site, amino acid sequence TVAD Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
caspase 6
-
Homo sapiens