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Literature summary for 3.4.22.59 extracted from

  • Foley, J.D.; Rosenbaum, H.; Griep, A.E.
    Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development (2004), J. Biol. Chem., 279, 32142-32150.
    View publication on PubMed
Search for more literature for 3.4.22.59

Application

Application Comment Organism
medicine difference between normal fiber cell differentation and apoptosis and the capacity of the lens to differentially regulate these two processes Mus musculus
medicine difference between normal fiber cell differentation and apoptosis and the capacity of the lens to differentially regulate these two processes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-Leu-vinylsulfone
-
 Homo sapiens
beta-lactone
-
 Homo sapiens
epoxomicin
-
 Homo sapiens
IETD-CHO caspase-6 in lens extracts from neonatal mice partially inhibited by 0.0005 mM Mus musculus
lactacystin
-
 Homo sapiens
VEID-CHO caspase-6 in lens extracts from neonatal mice efficiently inhibited by 0.0005 mM Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 neonatal FVB/n cell line and alphaAE7 transgenic mice line 75a (as a source of apoptotic lens cells)
-
Rattus norvegicus
-
 E15.5-18.5 embryos from Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
fiber primary fiber cells Rattus norvegicus
-
lens
-
 Mus musculus
-
lens
-
 Rattus norvegicus
-
leukemia cell THP-1 human monocytic cell culture Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 VEID-7-amido-4-trifluoromethylcoumarin cleavage acitivity overall increases by 6.1fold between E15.5 and E18.5 rat embryos Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IETD-7-amido-4-trifluoromethylcoumarin + H2O
-
 Mus musculus IETD + 7-amino-4-trifluoromethylcoumarin
-
 ?
IETD-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens IETD + 7-amino-4-trifluoromethylcoumarin
-
 ?
IETD-7-amido-4-trifluoromethylcoumarin + H2O very low cleavage activity Rattus norvegicus IETD + 7-amino-4-trifluoromethylcoumarin
-
 ?
VEID-7-amido-4-trifluoromethylcoumarin + H2O
-
 Rattus norvegicus VEID + 7-amino-4-trifluoromethylcoumarin
-
 ?
VEID-7-amido-4-trifluoromethylcoumarin + H2O preferred substrate for caspase-6 Mus musculus VEID + 7-amino-4-trifluoromethylcoumarin
-
 ?
VEID-7-amido-4-trifluoromethylcoumarin + H2O preferred substrate for caspase-6 Homo sapiens VEID + 7-amino-4-trifluoromethylcoumarin
-
 ?