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Literature summary for 3.4.22.59 extracted from

  • Schmeck, B.; Gross, R.; N'Guessan, P.D.; Hocke, A.C.; Hammerschmidt, S.; Mitchell, T.J.; Rosseau, S.; Suttorp, N.; Hippenstiel, S.
    Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium (2004), Infect. Immun., 72, 4940-4947.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.59

Application

Application Comment Organism
medicine Streptococcus pneumoniae induces apoptosis of human alveolar and bronchial epithelial cells, programmed cell death is excecuted by caspase 6, and can be blocked by overexpression of Bcl2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Ala-Asp-fluoromethylketone inhibitor of caspases Homo sapiens
ZVEID specific caspase 6 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar cell A549 cell line infected by unencapsulated Streptococcus pneumoniae type 2 strain R6x and capsulated Streptococcus pneumoniae strain D39 and the pneumolysin-deficient R6xply mutant Homo sapiens
-
bronchial epithelial cell line BEAS-2B cell line infected by unencapsulated Streptococcus pneumoniae type 2 strain R6x Homo sapiens
-
lung epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Val-Glu-Ile-Asp 4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
caspase 6
-
 Homo sapiens