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Literature summary for 3.4.22.59 extracted from

  • Galande, S.; Dickinson, L.A.; Mian, I.S.; Sikorska, M.; Kohwi-Shigematsu, T.
    SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis (2001), Mol. Cell. Biol., 21, 5591-5604.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SATB1 + H2O Homo sapiens cleavage disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SATB1 + H2O specifically cleaves at amino acid position 254 to produce a 65000 Da major fragment containing both a base-unpairing region (BUR)-binding domain and a homeodomain. This cleavage separates the DNA-binding domains from amino acids 90 to 204, a region which is a dimerization domain. The resulting SATB1 monomer loses its BUR-binding activity Homo sapiens ?
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 ?
SATB1 + H2O cleavage disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis Homo sapiens ?
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 ?