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Literature summary for 3.4.22.58 extracted from

  • Bian, Z.M.; Elner, S.G.; Khanna, H.; Murga-Zamalloa, C.A.; Patil, S.; Elner, V.M.
    Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells (2011), Invest. Ophthalmol. Vis. Sci., 52, 8646-8656.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.58

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of caspase-5 is enhanced by ATP and endoplasmic reticulum stress inducers, and 2.2-5.4fold by interleukin-1beta, TNF-alpha, lipopolysaccharide and hRPE cell co-culture, but not by IFN-gamma Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information stable knockdown of caspase-5 by shRNA3554 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information dexamethasone, interleukin-10, and triamcinolone acetonide block activation of caspase-5. Activation of caspase-5 is also inhibited by caspase-1-specific inhibitor Z-YVAD-FMK Homo sapiens
Z-VAD-fluoromethylketone pan-caspase inhibitor Homo sapiens
Z-WEHD-fluoromethylketone a caspase-5 and -1 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelial cell primary cultured hRPE cells, telomerase-immortalized hTERT-RPE1 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
WEHD-4-nitroanilide + H2O
-
 Homo sapiens WEHD + 4-nitroaniline
-
 ?

Expression

Organism Comment Expression
Homo sapiens expression of caspase-5 is inhibited by caspase-1-specific inhibitor Z-YVAD-fluoromethylketone down
Homo sapiens caspase-5 is induced 1.9-2.3fold by interleukin-1beta, TNF-alpha, lipopolysaccharide and hRPE cell co-culture, but not by IFN-gamma up

General Information

General Information Comment Organism
malfunction caspase-5 knockdown by shRNA reduces caspase-1 protein expression and activation and inhibited TNF-alpha–induced interleukin-8 and MCP-1 Homo sapiens
physiological function functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. Involvement of caspase-5 in tunicamycin-induced apoptotic cell death, similar to caspase-4, EC 3.4.22.57 Homo sapiens