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Literature summary for 3.4.22.57 extracted from
- TLR3 mediates release of IL-1beta and cell death in keratinocytes in a caspase-4 dependent manner (2013), J. Dermatol. Sci., 72, 45-53.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-acetyl-LEVD-CHO | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procaspase-1 + H2O | Homo sapiens | - |
caspase-1 + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keratinocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procaspase-1 + H2O | - |
Homo sapiens | caspase-1 + ? | - |
? | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | mRNA expression of the pro-form of caspase-4 is up-regulated 2fold after poly-I:C stimulation | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | caspase-4 is required for maturation of pro-interleukin-1beta through activation of caspase-1 in keratinocytes | Homo sapiens |
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