Literature summary for 3.4.22.57 extracted from

Yukioka, F.; Matsuzaki, S.; Kawamoto, K.; Koyama, Y.; Hitomi, J.; Katayama, T.; Tohyama, M.
Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis (2008), Neurochem. Int., 52, 683-687.

Search for more literature for 3.4.22.57

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	familial Alzheimer's disease-linked presenilin-1 mutation accelerates the cleavage of caspase-4 under the endoplasmic reticulum stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	familial Alzheimer's disease-linked presenilin-1 mutation accelerates the cleavage of caspase-4 under the endoplasmic reticulum stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)