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Literature summary for 3.4.22.57 extracted from

  • Kamens, J.; Paskind, M.; Hugunin, M.; Talanian, R.V.; Allen, H.; Banach, D.; Bump, N.J.; Hackett, M.C.; Johnston, C.G.; Li, P.; Mankovich, J.A.; Terranova, M.; Ghayur, T.
    Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases (1995), J. Biol. Chem., 270, 15250-15256.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetyl-YVD-aldehyde IC50: 748 nM Homo sapiens
iodoacetamide
-
Homo sapiens
iodoacetic acid
-
Homo sapiens
additional information no inhibition by E64 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.681
-
acetyl-Tyr-Val-Ala-Asp-4-nitroanilide pH 7.0, 30°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens overexpression of ICH-2 in insect cell induces apoptosis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49662
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
heart
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
additional information no activity detected in brain Homo sapiens
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spleen
-
Homo sapiens
-
testis
-
Homo sapiens
-
thymus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Tyr-Val-Ala-Asp-4-nitroanilide + H2O
-
Homo sapiens acetyl-Tyr-Val-Ala-Asp + 4-nitroaniline
-
?
additional information overexpression of ICH-2 in insect cell induces apoptosis Homo sapiens ?
-
?
pro-interleukin-1beta + H2O
-
Homo sapiens additional information generation of a small amount of mature interleukin-1beta after 120 min ?
succinyl-YVAD-4-nitroanilide + H2O
-
Homo sapiens succinyl-YVAD + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
More purified N-His IVH-2 migrates on an SDS-PAGE as two bands with approximately molecular masses of 20000 Da and 10000 Da Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000748
-
IC50: 748 nM Homo sapiens acetyl-YVD-aldehyde