Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-YVD-aldehyde | IC50: 748 nM | Homo sapiens | |
iodoacetamide | - |
Homo sapiens | |
iodoacetic acid | - |
Homo sapiens | |
additional information | no inhibition by E64 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.681 | - |
acetyl-Tyr-Val-Ala-Asp-4-nitroanilide | pH 7.0, 30°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | overexpression of ICH-2 in insect cell induces apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P49662 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
additional information | no activity detected in brain | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Tyr-Val-Ala-Asp-4-nitroanilide + H2O | - |
Homo sapiens | acetyl-Tyr-Val-Ala-Asp + 4-nitroaniline | - |
? | |
additional information | overexpression of ICH-2 in insect cell induces apoptosis | Homo sapiens | ? | - |
? | |
pro-interleukin-1beta + H2O | - |
Homo sapiens | additional information | generation of a small amount of mature interleukin-1beta after 120 min | ? | |
succinyl-YVAD-4-nitroanilide + H2O | - |
Homo sapiens | succinyl-YVAD + 4-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | purified N-His IVH-2 migrates on an SDS-PAGE as two bands with approximately molecular masses of 20000 Da and 10000 Da | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000748 | - |
IC50: 748 nM | Homo sapiens | acetyl-YVD-aldehyde |