Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.57 extracted from

  • Munday N.A.; Vaillancourt J.P.; Ali A.; Casano F.J.; Miller D.K.; Molineaux S.M.; Yamin T.T.; Yu V.L.; Nicholson D.W.
    Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases (1995), J. Biol. Chem., 270, 15870-15876.
    View publication on PubMed
Search for more literature for 3.4.22.57

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
full-length clones are originally transfected into various host cells, including COS-M6, RAT-1 and HeLa Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is capable of inducing apoptosis in transfected cells such as fibroblasts and may play a role in apoptotic cell death ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49662
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification synthesized as larger proenzyme which is proteolytically processed to form heterodimeric active enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
additional information no activity detected in brain Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is capable of inducing apoptosis in transfected cells such as fibroblasts and may play a role in apoptotic cell death Homo sapiens ?
-
 ?