Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-CV3-KE | - |
Homo sapiens | |
Ac-DW3-KE | - |
Homo sapiens | |
Ac-F-D-beta-hLeu-hLeu-D-KE | - |
Homo sapiens | |
FAM-Ahx2-CV3-AOMK | - |
Homo sapiens | |
FAM-DEVD-AOMK | - |
Homo sapiens | |
methyl N-acetyl-3-(pyridin-3-yl)-D-alanyl-N-[[(3S)-1-[(2R)-1-[(3S)-1-methoxy-5-[[(5-methylthiophen-2-yl)carbonyl]oxy]-1,4-dioxopentan-3-yl]amino-1-oxo-3-phenylpropan-2-yl]amino]-5-methyl-1-oxohexan-3-yl]-L-alpha-asparaginate | low nanomolar potency against caspase-3 with more than 120fold selectivity over caspase-7 | Homo sapiens | |
N-acetyl-3-(pyridin-3-yl)-L-alanyl-N-[(3S)-1-[[(2S)-1-([(2S)-1-carboxy-4-[(2,6-dimethylbenzoyl)oxy]-3-oxobutan-2-yl]amino)-5-methyl-1-oxohexan-2-yl]amino]-5-methyl-1-oxohexan-3-yl]-L-alpha-asparagine | low nanomolar potency against caspase-3 with more than 30fold selectivity over caspase-7 | Homo sapiens | |
Rho-DEVD-AOMK | - |
Homo sapiens | |
Z-VAD-fluoromethylketone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-DEVD-7-amido-4-fluoromethylcoumarin + H2O | - |
Homo sapiens | N-acetyl-DEVD + 7-amino-4-fluoromethylcoumarin | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000068 | - |
at pH 7.4 and 22°C | Homo sapiens | Ac-CV3-KE | |
0.00001 | - |
at pH 7.4 and 22°C | Homo sapiens | Rho-DEVD-AOMK | |
0.000012 | - |
at pH 7.4 and 22°C | Homo sapiens | Ac-F-D-beta-hLeu-hLeu-D-KE | |
0.000018 | - |
at pH 7.4 and 22°C | Homo sapiens | FAM-DEVD-AOMK | |
0.000023 | - |
at pH 7.4 and 22°C | Homo sapiens | N-acetyl-3-(pyridin-3-yl)-L-alanyl-N-[(3S)-1-[[(2S)-1-([(2S)-1-carboxy-4-[(2,6-dimethylbenzoyl)oxy]-3-oxobutan-2-yl]amino)-5-methyl-1-oxohexan-2-yl]amino]-5-methyl-1-oxohexan-3-yl]-L-alpha-asparagine | |
0.000027 | - |
at pH 7.4 and 22°C | Homo sapiens | FAM-Ahx2-CV3-AOMK | |
0.01 | - |
at pH 7.4 and 22°C | Homo sapiens | Ac-DW3-KE |