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BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Katao, Y.; Shishido, M.; Inami, K.; Matsumoto, N.; Sawai, H.
    An inhibitory role for caspase-3 at the late stage of RANKL-induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages (2014), Cell Biol. Int., 38, 723-728.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Z-Asp-2,6-dichlorobenzoyloxymethylketone a caspase-3-specific inhibitor Mus musculus
Z-VAD-fluoromethylketone a pan-caspase inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived macrophage
-
Mus musculus
-
RAW-264 cell
-
Mus musculus
-

General Information

General Information Comment Organism
malfunction caspase-3-specific inhibition augments RANKL-induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages Mus musculus
physiological function activation of caspase-3 plays an inhibitory role at the late stage of RANKL-induced osteoclast differentiation Mus musculus