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Literature summary for 3.4.22.56 extracted from
- Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism (2015), Biochem. Biophys. Res. Commun., 456, 810-814.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3-[(dodecylthiocarbonyl)methyl]glutarimide | - |
Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-acetyl-DEVD-CHO | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RelB + H2O | Homo sapiens | the Asp205 site in RelB is specifically cleaved by caspase-3 in vinblastine-treated HAT-1080 cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HT-1080 cell | - |
Homo sapiens | - |
| lymphoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RelB + H2O | the Asp205 site in RelB is specifically cleaved by caspase-3 in vinblastine-treated HAT-1080 cells | Homo sapiens | ? | - |
? | |
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