Literature summary for 3.4.22.56 extracted from

Chen, G.; Gao, H.; Tang, J.; Huang, Y.; Chen, Y.; Wang, Y.; Zhao, H.; Lin, H.; Xie, Q.; Hong, K.; Li, J.; Yao, X.
Benzamides and quinazolines from a mangrove actinomycetes Streptomyces sp. (No. 061316) and their inhibiting caspase-3 catalytic activity in vitro (2011), Chem. Pharm. Bull., 59, 447-451.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-hydroxyl-anthranilamide	inhibits caspase-3, the compound is isolated from Streptomyces sp., a mangrove actinomycete, strain 061316	Rattus norvegicus
8-hydroxyl-2,4-dioxoquinazoline	inhibits caspase-3, the compound is isolated from Streptomyces sp., a mangrove actinomycete, strain 061316	Rattus norvegicus
additional information	no inhibitory activity of compounds 3-hydroxyl-2-N-iso-butyryl-anthranilamide, anthranilamide, 8-hydroxyl-4(3H)-quinazoline, and 8-hydroxyl-2-methyl-4(3H)-quinazoline from Streptomyces sp., a mangrove actinomycete, strain 061316	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	recombinant enzyme	Rattus norvegicus	-
PC-12 cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-DEVD-4-nitroanilide + H2O	-	Rattus norvegicus	Ac-DEVD + 4-nitroaniline	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
35	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.032	-	pH 7.5, 35°C	Rattus norvegicus	3-hydroxyl-anthranilamide
0.036	-	pH 7.5, 35°C	Rattus norvegicus	8-hydroxyl-2,4-dioxoquinazoline

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Release 2023.1 (January 2023)