Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DEVD-fluoromethylketone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-29 cell | - |
Homo sapiens | - |
MA-104 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DEVD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | DEVD + 7-amino-4-trifluoromethylcoumarin | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in contrast to low XIAP expression, the A5-16 strain shows enhanced cleavage of caspase-3 as early as 8 hours post infection with a 6-8fold increase by 12 hours post infection. There is a significant increase in caspase-3 activity (2-3fold) at an early stage of infection (4-8 hours post infection) in mutant strain A5-16-infected cells compared to the A5-13 infection. At 12-18 hours post infection, the caspase-3 activity in A5-13-infected cells increases significantly relative to mock-infected controls | up |