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Literature summary for 3.4.22.56 extracted from

  • Teschendorf, P.; Vogel, P.; Wippel, A.; Krumnikl, J.J.; Spoehr, F.; Boettiger, B.W.; Popp, E.
    The effect of intracerebroventricular application of the caspase-3 inhibitor zDEVD-FMK on neurological outcome and neuronal cell death after global cerebral ischaemia due to cardiac arrest in rats (2008), Resuscitation, 78, 85-91.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
carboxyfluorescein-valyl-alanyl-aspartic-acid fluoromethyl ketone the FAM-peptide irreversibly binds to active caspases Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
caspase-3 expression analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
N-benzyloxycarbonyl-valyl-alanyl-aspartic-acid fluoromethyl ketone
-
 Rattus norvegicus
N-carbobenzyloxy-DEVD-fluoromethyl ketone a specific caspase-3 inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus activation of caspase-3, an executioner caspase, plays a key role in the apoptotic cascade ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
neuronal cell line
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of caspase-3, an executioner caspase, plays a key role in the apoptotic cascade Rattus norvegicus ?
-
 ?