Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | direct activation of procaspase-3 by caspase-9 and caspase-8 in type I cells through proteolytic cleavage | Rattus norvegicus | |
TNF-alpha/irradiation | leads to an increase of caspase-3, administration of TNF-alpha to non-irradiated hepatocytes does not lead to an increased activity of caspase-3, administration of TNF-alpha to non-irradiated hepatocytes does not lead to an increased activity of caspase-3. Irradiation induces TNF-alpha-mediated activation of caspase-3, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-3 activation, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | IkappaB-antisense oligonucleotides inhibit caspase-9 but also caspase-3 activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | co-localization with Fas death domain, FADD | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | direct activation of procaspase-3 by caspase-9 and caspase-8 in type I cells, radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview. Irradiation induces TNF-alpha-mediated activation of caspase-8, -9, and -3, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-3 is activated by cleavage through caspase-8 and caspase-9 leading to apoptosis | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
additional information | type I cells generate high levels of caspase-3 | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | direct activation of procaspase-3 by caspase-9 and caspase-8 in type I cells, radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview. Irradiation induces TNF-alpha-mediated activation of caspase-8, -9, and -3, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, overview | Rattus norvegicus | ? | - |
? | |
additional information | procaspase-3 is activated by caspase-9 and caspase-8 | Rattus norvegicus | ? | - |
? |