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Literature summary for 3.4.22.56 extracted from

  • Guerleyen, H.; Christiansen, H.; Tello, K.; Dudas, J.; Hermann, R.M.; Rave-Fraenk, M.; Hess, C.F.; Ramadori, G.; Saile, B.
    Irradiation leads to sensitization of hepatocytes to TNF-alpha-mediated apoptosis by upregulation of IkappaB expression (2009), Radiat. Environ. Biophys., 48, 85-94.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information direct activation of procaspase-3 by caspase-9 and caspase-8 in type I cells through proteolytic cleavage Rattus norvegicus
TNF-alpha/irradiation leads to an increase of caspase-3, administration of TNF-alpha to non-irradiated hepatocytes does not lead to an increased activity of caspase-3, administration of TNF-alpha to non-irradiated hepatocytes does not lead to an increased activity of caspase-3. Irradiation induces TNF-alpha-mediated activation of caspase-3, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-3 activation, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information IkappaB-antisense oligonucleotides inhibit caspase-9 but also caspase-3 activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information co-localization with Fas death domain, FADD Rattus norvegicus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus direct activation of procaspase-3 by caspase-9 and caspase-8 in type I cells, radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview. Irradiation induces TNF-alpha-mediated activation of caspase-8, -9, and -3, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-3 is activated by cleavage through caspase-8 and caspase-9 leading to apoptosis Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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Rattus norvegicus
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additional information type I cells generate high levels of caspase-3 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information direct activation of procaspase-3 by caspase-9 and caspase-8 in type I cells, radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis additionally requires changes upstream of caspase-8 activation, regulation of caspase-8 and apoptosis in hepatocytes, overview. Irradiation induces TNF-alpha-mediated activation of caspase-8, -9, and -3, and apoptosis in hepatocytes. Apoptosis induction is prevented by IkappaB antisense oligonucleotides mediated by suppression of caspases-9 and -3 activation but not of caspase-8 activation, overview Rattus norvegicus ?
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?
additional information procaspase-3 is activated by caspase-9 and caspase-8 Rattus norvegicus ?
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