Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | caspase-3 activity within cells is slightly increased after treatment of free heparin for 2 day, internalized heparin triggers apoptosis-inducing stimuli for activation of caspases and subsequent apoptotic cell death | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | caspases are a family of cysteine aspartic acid-specific proteases playing an important role in apoptotic processes in mammalian cells. Among them, caspase-3 is an essential protease that degrades other protein substrates inside the cells at an early stage of apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16-F10 cell | - |
Mus musculus | - |
melanoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Asp-Glu-Val-Asp-4-nitroanilide + H2O | caspase-3 specific substrate | Mus musculus | Asp-Glu-Val-Asp + 4-nitroaniline | - |
? | |
additional information | caspases are a family of cysteine aspartic acid-specific proteases playing an important role in apoptotic processes in mammalian cells. Among them, caspase-3 is an essential protease that degrades other protein substrates inside the cells at an early stage of apoptosis | Mus musculus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |