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Literature summary for 3.4.22.56 extracted from

  • Bae, K.H.; Moon, C.W.; Lee, Y.; Park, T.G.
    Intracellular delivery of heparin complexed with chitosan-g-poly(ethylene glycol) for inducing apoptosis (2009), Pharm. Res., 26, 93-100.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-3 activity within cells is slightly increased after treatment of free heparin for 2 day, internalized heparin triggers apoptosis-inducing stimuli for activation of caspases and subsequent apoptotic cell death Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspases are a family of cysteine aspartic acid-specific proteases playing an important role in apoptotic processes in mammalian cells. Among them, caspase-3 is an essential protease that degrades other protein substrates inside the cells at an early stage of apoptosis ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-F10 cell
-
Mus musculus
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melanoma cell
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Asp-Glu-Val-Asp-4-nitroanilide + H2O caspase-3 specific substrate Mus musculus Asp-Glu-Val-Asp + 4-nitroaniline
-
?
additional information caspases are a family of cysteine aspartic acid-specific proteases playing an important role in apoptotic processes in mammalian cells. Among them, caspase-3 is an essential protease that degrades other protein substrates inside the cells at an early stage of apoptosis Mus musculus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus