Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cytochrome c | induces caspas-3 activation | Homo sapiens | |
additional information | ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning and ischemic tolerance can diminish the activation of caspase-3, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
diagnostics | active caspase-3 immunostaining is considered as a highly reliable and specific morphological marker of early apoptosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning with 6,7,8,9-tetrahydro-5-nitro-1 H-benz[g]indole-2,3-dione-3-oxime, i.e. NS102, and ischemic tolerance can diminish the activation of caspase-3, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-3 activation results in apoptosis, ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning and ischemic tolerance can diminish the activation of caspase-3, regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-3 activation results in apoptosis, ischemic/reperfusion in brain leads to increased release of cytochrome c from mitochondria and activation of caspase-3, ischemic preconditioning and ischemic tolerance can diminish the activation of caspase-3, regulation, overview | Homo sapiens | ? | - |
? |