Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Amantini, C.; Mosca, M.; Lucciarini, R.; Perfumi, M.C.; Santoni, G.
    Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity (2008), J. Pharmacol. Exp. Ther., 327, 215-225.
    View publication on PubMed
Search for more literature for 3.4.22.56

Inhibitors

Inhibitors Comment Organism Structure
additional information thiorphan, a specific NEP/CD10 inhibitor, causes downregulation of procaspase-3 mRNA levels and suppression of caspase-3 activity in a neurokinin-1 receptor-dependent manner. The effect is abrogated by the NK1R antagonist (S)1-{2-[3(3-4-dichlorophenyl)-1-(3-iso-propoxyphenylacetyl)-piperidine-3-yl]ethyl}-4-pheny-1-azoniabicyclo[2.2.2]octane, chloride, i.e. SR140333, overview Rattus norvegicus
survivin inhibits processing of procaspase-3 and specifically binds the active form of caspase-3 through a baculovirus inhibitor of apoptosis, IAP, repeat domain Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus caspase-3 is involved in apoptosis in thymocytes, enzyme inhibition increases cell survival, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-3 is activated from procaspase-3 by cleavage Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
thymocyte constitutive caspase-3 activity Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-3 is involved in apoptosis in thymocytes, enzyme inhibition increases cell survival, regulation, overview Rattus norvegicus ?
-
 ?