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Literature summary for 3.4.22.56 extracted from

  • Delloye-Bourgeois, C.; Brambilla, E.; Coissieux, M.M.; Guenebeaud, C.; Pedeux, R.; Firlej, V.; Cabon, F.; Brambilla, C.; Mehlen, P.; Bernet, A.
    Interference with netrin-1 and tumor cell death in non-small cell lung cancer (2009), J. Natl. Cancer Inst., 101, 237-247.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-3 activity is increased in cells with inhibited nectrin-1 or deleted nectrin-1 receptors, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DEVD-fluoromethyl ketone a caspase-3-specific inhibitor Homo sapiens
N-benzyloxycarbonyl-VAD-fluoromethyl ketone a general caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens netrin-1 siRNA-induced H-358 cell death is mediated by caspase-3 and -9 activities, but not by caspase-8 activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
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NCI-H358 cell
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 Homo sapiens
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non-small cell lung cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 relative caspase-3 activity in nectrin-1-expressing and nectrin-1-deficient lung cancer cells, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information netrin-1 siRNA-induced H-358 cell death is mediated by caspase-3 and -9 activities, but not by caspase-8 activity Homo sapiens ?
-
 ?