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Literature summary for 3.4.22.56 extracted from

  • Parish, S.T.; Wu, J.E.; Effros, R.B.
    Modulation of T lymphocyte replicative senescence via TNF-{alpha} inhibition: role of caspase-3 (2009), J. Immunol., 182, 4237-4243.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information TNF-alpha induces the enzyme activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens constitutive caspase-3 is one of the downstream effectors of TNF-alpha receptor-1 binding, that increases in parallel with the loss of CD28 in long-term T lymphocyte cultures, but this effect is blunted in the presence of the TNF-alpha inhibitors ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte CD8+CD28- T lymphocytes show significantly higher levels of caspase-3 compared with their CD28+ counterparts Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information constitutive caspase-3 is one of the downstream effectors of TNF-alpha receptor-1 binding, that increases in parallel with the loss of CD28 in long-term T lymphocyte cultures, but this effect is blunted in the presence of the TNF-alpha inhibitors Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens