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Literature summary for 3.4.22.56 extracted from

  • Jeong, I.G.; Kim, S.H.; Jeon, H.G.; Kim, B.H.; Moon, K.C.; Lee, S.E.; Lee, E.
    Prognostic value of apoptosis-related markers in urothelial cancer of the upper urinary tract (2009), Hum. Pathol., 40, 668-677.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
cytochrome c activates caspase-3 after being released from mitochondria Homo sapiens

Application

Application Comment Organism
diagnostics caspase-3 is a marker for apoptosis, e.g. useful in patients with urothelial carcinoma of the upper urinary tract, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Bcl-2 an antiapoptotic protein that is localized to the intracellular membrane, nuclear membrane and endoplasmic reticulum, and blocks caspase activation by inhibiting the mitochondrial release of cytochrome c Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-3 has a downstream effector function in apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
urinary tract upper part, expression of caspase-3 is associated with the pathologic stage in urothelial carcinomas, immunohistochemic analysis, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-3 has a downstream effector function in apoptosis Homo sapiens ?
-
 ?