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Literature summary for 3.4.22.56 extracted from

  • Mustonen, H.; Puolakkainen, P.; Kemppainen, E.; Kiviluoto, T.; Kivilaakso, E.
    Taurocholate potentiates ethanol-induced NF-kappaB activation and inhibits caspase-3 activity in cultured rat gastric mucosal cells (2009), Digest. Dis. Sci., 54, 928-936.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information ethanol and acetylsalicylic acid induce caspase-3 activation, which is inhibited by taurocholate at low concentrations of 0.00001-0.1 mM Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
taurocholate at low concentrations of 0.00001-0.1 mM it increases caspase-3 activity, but at larger doses of 0.5-10 mM it reverses stimulation to inhibition. It inhibits the caspase-3 pathway and prevents ethanol-induced caspase-3 activation leading to inhibition of apoptosis, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme regulation in response to damaging agents like ethanol and acetylsalicylic acid in gastric mucosa, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture
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 Rattus norvegicus
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mucosa
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 Rattus norvegicus
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RGM-1 cell gastric mucosal cell Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme regulation in response to damaging agents like ethanol and acetylsalicylic acid in gastric mucosa, overview Rattus norvegicus ?
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 ?