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Literature summary for 3.4.22.56 extracted from

  • Meier, M.; Nitschke, M.; Hocke, C.; Kramer, J.; Jabs, W.; Steinhoff, J.; Schutt, M.
    Insulin inhibits caspase-3 activity in human renal tubular epithelial cells via the PI3-kinase/Akt pathway (2008), Cell. Physiol. Biochem., 21, 279-286.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
additional information camptothecin incubation results in an approximately 3fold increase of the caspase-3 activity in renal tubular epithelial cells associated with a significant decrease of cell number Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information insulin inhibits caspase-3 activity 30-60% in renal tubular epithelial cells via the PI3-kinase/Akt pathway, insulin deprivation for 24 or 48 h leads to a significant increase of the caspase-3 enzyme activity by 15% and 58%, respectively Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens insulin inhibits caspase-3 activity in renal tubular epithelial cells via the PI3-kinase/Akt pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
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kidney renal tubule Homo sapiens
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renal tubule
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information insulin inhibits caspase-3 activity in renal tubular epithelial cells via the PI3-kinase/Akt pathway Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens