Inhibitors | Comment | Organism | Structure |
---|---|---|---|
inhibitor of apoptosis protein | IAP, the family members block effector caspase-3 further downstream, which potentially inhibits apoptosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | TRAIL and TRAIL death receptors form a complex, which transmits an apoptotic signal via the Fas associated death domain leading to activation of caspase-8 or other initiator caspases, which in turn activate downstream caspases, such as caspase-3, 9, 6 and 7, that cause cell death, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | caspase-3 is activated by cleavage | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
synovial tissue | from healthy and arthritic individuals | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | TRAIL and TRAIL death receptors form a complex, which transmits an apoptotic signal via the Fas associated death domain leading to activation of caspase-8 or other initiator caspases, which in turn activate downstream caspases, such as caspase-3, 9, 6 and 7, that cause cell death, overview | Homo sapiens | ? | - |
? |