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Literature summary for 3.4.22.56 extracted from

  • Clements, K.M.; Burton-Wurster, N.; Nuttall, M.E.; Lust, G.
    Caspase-3/7 inhibition alters cell morphology in mitomycin-C treated chondrocytes (2005), J. Cell. Physiol., 205, 133-140.
    View publication on PubMed

Application

Application Comment Organism
medicine induction of apoptosis with mitomycin-c in presence or absence of general caspase inhibitor benzoyl-Val-Ala-Asp-fluoromethylketone. Benzoyl-Val-Ala-Asp-fluoromethylketone prevents mitomycin-c-induced cell death. In contrast, specific inhibition of enzyme or caspase-7 in presence of mitomycin-c induces necrotic-like or paraptotic-like morphological changes but does not prevent cell death Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte induction of apoptosis with mitomycin-c in presence or absence of general caspase inhibitor benzoyl-Val-Ala-Asp-fluoromethylketone. Benzoyl-Val-Ala-Asp-fluoromethylketone prevents mitomycin-c-induced cell death. In contrast, specific inhibition of enzyme or caspase-7 in presence of mitomycin-c induces necrotic-like or paraptotic-like morphological changes but does not prevent cell death Canis lupus familiaris
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