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Literature summary for 3.4.22.56 extracted from

  • Rheaume, E.; Cohen, L.Y.; Uhlmann, F.; Lazure, C.; Alam, A.; Hurwitz, J.; Sekaly, R.P.; Denis, F.
    The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis (1997), EMBO J., 16, 6346-6354.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
acetyl-DEVD-aldehyde
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RFC140 + H2O Homo sapiens cleavage of RFC140 during apoptosis inactivates its function in DNA replication and generates truncated forms that further inhibit DNA replication ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(ADP-ribose) polymerase + H2O caspase cleaves at a DEVD-G motif Homo sapiens ?
-
 ?
RFC140 + H2O cleavage at three sites: DEVD723G, DLVD922S and IETD1117A Homo sapiens ?
-
 ?
RFC140 + H2O cleavage of RFC140 during apoptosis inactivates its function in DNA replication and generates truncated forms that further inhibit DNA replication Homo sapiens ?
-
 ?