Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-DEVD-aldehyde | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RFC140 + H2O | Homo sapiens | cleavage of RFC140 during apoptosis inactivates its function in DNA replication and generates truncated forms that further inhibit DNA replication | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ADP-ribose) polymerase + H2O | caspase cleaves at a DEVD-G motif | Homo sapiens | ? | - |
? | |
RFC140 + H2O | cleavage at three sites: DEVD723G, DLVD922S and IETD1117A | Homo sapiens | ? | - |
? | |
RFC140 + H2O | cleavage of RFC140 during apoptosis inactivates its function in DNA replication and generates truncated forms that further inhibit DNA replication | Homo sapiens | ? | - |
? |