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Literature summary for 3.4.22.56 extracted from

  • Erhadt, P.; Tomaselli, K.J.; Cooper, G.M.
    Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases (1997), J. Biol. Chem., 272, 15049-15052.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
MDM2 oncoprotein + H2O Homo sapiens because MDM2 functions as a negative regulator of the p53 tumor suppressor and because p53 induces apoptosis in response to a variety of stimuli, this cleavage of MDM2 by CPP32-like proteases may result in deregulation of p53 and contribute directly to the process of apoptotic cell death ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme expressed in Escherichia coli
-

Source Tissue

Source Tissue Comment Organism Textmining
697 cell
-
Homo sapiens
-
pheochromocytoma cell
-
Homo sapiens
-
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MDM2 oncoprotein + H2O
-
Homo sapiens ?
-
?
MDM2 oncoprotein + H2O because MDM2 functions as a negative regulator of the p53 tumor suppressor and because p53 induces apoptosis in response to a variety of stimuli, this cleavage of MDM2 by CPP32-like proteases may result in deregulation of p53 and contribute directly to the process of apoptotic cell death Homo sapiens ?
-
?