Literature summary for 3.4.22.55 extracted from

Boonstra, K.; Bloemberg, D.; Quadrilatero, J.
Caspase-2 is required for skeletal muscle differentiation and myogenesis (2018), Biochim. Biophys. Acta Mol. Cell Res., 1865, 95-104 .

Search for more literature for 3.4.22.55

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	caspase-2 and p21 are localized to the nucleus during early differentiation	Mus musculus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P29594	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	caspase-2 activity transiently increases more than two-fold within 24 h following induction of differentiation	Mus musculus	-

General Information

General Information	Comment	Organism
malfunction	both pharmacological inhibition and shRNA-mediated knockdown of caspase-2 suppresses myogenic differentiation and dramatically impaired myotube formation	Mus musculus
physiological function	caspase-2 is required for skeletal muscle differentiation and myogenesis. The role of caspase-2 is to regulate p21 induction at the onset of differentiation, which may regulate the myogenic program	Mus musculus

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Release 2023.1 (January 2023)