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Literature summary for 3.4.22.55 extracted from

  • Oliver, T.G.; Meylan, E.; Chang, G.P.; Xue, W.; Burke, J.R.; Humpton, T.J.; Hubbard, D.; Bhutkar, A.; Jacks, T.
    Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop (2011), Mol. Cell, 43, 57-71.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
p53-induced protein with a death domain PIDD, caspase-2 is activated by the p53 target gene product PIDD, i.e. LRDD or leucine-rich repeats and death domain containing, in a complex called the caspase-2-PIDDosome Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Mdm2 + H2O Homo sapiens Mdm2 is a key negative regulator of p53 processed Mdm2 + p60
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NSCLC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mdm2 + H2O Mdm2 is a key negative regulator of p53 Homo sapiens processed Mdm2 + p60
-
?
Mdm2 + H2O Mdm2 contains a well-conserved caspase cleavage site, Asp-Val-Pro-Asp or DVPD, at which cleavage generates an 60 kDa N-terminal product. No activity with Mdm2 mutants D367A and D367E Homo sapiens processed Mdm2 + p60
-
?

Expression

Organism Comment Expression
Homo sapiens caspase-2 induction by p53 up

General Information

General Information Comment Organism
evolution caspase-2 is an evolutionarily conserved caspase with features of both initiator and executioner caspases Homo sapiens
physiological function upon DNA damage, p53 induction of the Caspase-2-PIDDosome creates a positive feedback loop that inhibits Mdm2, a key negative regulator of p53, and reinforces p53 stability and activity, contributing to cell survival and drug resistance, mechanism of Mdm2 inhibition that impacts p53 dynamics upon genotoxic stress, overview Homo sapiens