Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p53-induced protein with a death domain | PIDD, caspase-2 is activated by the p53 target gene product PIDD, i.e. LRDD or leucine-rich repeats and death domain containing, in a complex called the caspase-2-PIDDosome | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mdm2 + H2O | Homo sapiens | Mdm2 is a key negative regulator of p53 | processed Mdm2 + p60 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NSCLC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mdm2 + H2O | Mdm2 is a key negative regulator of p53 | Homo sapiens | processed Mdm2 + p60 | - |
? | |
Mdm2 + H2O | Mdm2 contains a well-conserved caspase cleavage site, Asp-Val-Pro-Asp or DVPD, at which cleavage generates an 60 kDa N-terminal product. No activity with Mdm2 mutants D367A and D367E | Homo sapiens | processed Mdm2 + p60 | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | caspase-2 induction by p53 | up |
General Information | Comment | Organism |
---|---|---|
evolution | caspase-2 is an evolutionarily conserved caspase with features of both initiator and executioner caspases | Homo sapiens |
physiological function | upon DNA damage, p53 induction of the Caspase-2-PIDDosome creates a positive feedback loop that inhibits Mdm2, a key negative regulator of p53, and reinforces p53 stability and activity, contributing to cell survival and drug resistance, mechanism of Mdm2 inhibition that impacts p53 dynamics upon genotoxic stress, overview | Homo sapiens |