Literature summary for 3.4.22.55 extracted from

Olsson, M.; Vakifahmetoglu, H.; Abruzzo, P.M.; Hoegstrand, K.; Grandien, A.; Zhivotovsky, B.
DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis (2009), Oncogene, 28, 1949-1959.

Search for more literature for 3.4.22.55

Cloned(Commentary)

Cloned (Comment)	Organism
in vitro translation, His6-tagged protein expressed in Escherichia coli BL21	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Val-Asp-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O	Homo sapiens	-	Val-Asp-Val-Ala-Asp + 7-amino-4-methylcoumarin	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	pattern of caspase-2 processing differs between its autocatalytic and caspase-8-mediated cleavage	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
immobilized metal ion affinity chromatography (Ni2+)	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Val-Asp-Val-Ala-Asp-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Val-Asp-Val-Ala-Asp + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
caspase-2	-	Homo sapiens

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Release 2023.1 (January 2023)